Catherine Acquadro PhD

Catherine Acquadro

PhD

Catherine Acquadro provides medical advice at Mapi Research Trust and Mapi (PCO, Language Services, and Real World Evidence).

Dr. Acquadro is actively involved in scientific communication, in the development of collaborative projects, and in the new developments and audit of MRT databases (PROQOLID, PROlabels, PMR and Outcomes Insite).

Dr. Acquadro received her MD from the University of Grenoble (France) in 1990. Her medical thesis was about Inikagapi, a Lakota (Sioux) ritual of healing and renewal (sweat lodge).

Dr. Acquadro joined Mapi in 1991 to create the Quality of Life Newsletter, known now as the Patient-Reported Outcomes Newsletter.

In 1992, she was the European-based coordinator of the International Quality of Life Assessment (IQOLA) Project (cultural adaptation of the SF-36 in other languages) under the direction of John Ware. She was involved in the early development of the linguistic validation methodology to translate health-related quality of life (HRQL) instruments for use in multi-national clinical trials.

In 1995, Dr. Acquadro was the first Managing Director of Mapi Research Trust. From 1997 to 2007, she was the coordinator of the European Regulatory Issues on Quality of Life Assessment (ERIQA) Group, and from 2000 to 2002 the coordinator of the Patient-Reported Outcome (PRO) Harmonization Group. These two projects were pioneers and instrumental in the recognition of PROs as valid criteria for the evaluation of medicines, by regulatory bodies such as the Food and Drug Administration (FDA) and the European Agency of Medicines (EMA). They contributed to the development of the FDA guidance on PRO measures and the EMA reflection paper on HRQL. Dr. Acquadro was also co-convenor of the Cochrane Collaboration PRO Methods Group from 2001 to 2007 with Donald Patrick and Gordon Guyatt.

From 1997 to 2001, she worked closely with the French Cochrane Center to convince the Cochrane Collaboration of the usefulness of including PROs in systematic reviews. The PROs Methods Group’s main objective is to advise Cochrane reviewers about when and how to incorporate PROs into systematic reviews.

Employment History / Recent Positions

July 2009 – present, Independent Consultant

Jan 2007 – June 2009, Senior Project Manager
PRO Unit, Saint Louis Hospital, Paris – Development of the PROQOL- HIV measure

October 1996 – December 2006, Scientific Advisor Mapi Group
Mapi Group, Lyon, France

October 1995 – July 2000, General practitioner
Grenoble, Les Abrets, Vif – France

January 1995 – July 1995, Executive Managing Director
Development and creation of Mapi Research Institute,
Lyon, France

August 1991 – December 1994, Project Manager,
Development and creation of Mapi Research Institute,
Lyon, France

Education

Pierre et Marie Curie University (Paris VI)
1994 : Statistics applied to Medicines - Clinical Research
Option (CESAM- STARC) : Inter-University Diploma

Management Institute of Health Industries (IMIS)
1991 : Pharmaceutical Marketing and Management : Master’s degree

Joseph Fourier University (UJF)
1990 : Medicine : M.D.

Publications

  • Rofail D, Acquadro C, Izquierdo C, Regnault A, Zarit SH. Cross-cultural adaptation of the Schizophrenia Caregiver Questionnaire (SCQ) and the Caregiver Global Impression (CaGI) Scales in 11 languages. Health Qual Life Outcomes. 2015 Jun 9;13:76.
  • Acquadro C, Bayles A, Juniper E. Translating patient-reported outcome measures: a multi-step process is essential. J Bras Pneumol. 2014 May-Jun;40(3):211-2. English, Portuguese.
  • Conway K, Acquadro C, Patrick DL. Usefulness of translatability assessment: results from a retrospective study. Qual Life Res. 2014 May;23(4):1199-210.
  • Brédart A, Marrel A, Abetz-Webb L, Lasch K, Acquadro C. Interviewing to develop Patient-Reported Outcome (PRO) measures for clinical research: eliciting patients' experience. Health Qual Life Outcomes. 2014 Feb 5;12:15.

Abstracts/Invited Presentations/Invited Expert

  • Acquadro C. Patient-Reported Outcomes (PROs) in Drug Development. In: PROs in Hematology. Invited Presentation. 57th American Society of Hematology (ASH), Annual Meeting, December 5-8, 2015 Orlando, FL, USA.
  • Acquadro C. Linguistic Validation of PRO measures: How? In: Translation and cultural issues in PRO outcome measures. Invited Presentation. 20th Annual Rehabilitation in Multiple Sclerosis (RIMS) Conference, April 9-11, 2015, Milan, Italy.
  • Acquadro C. Invited expert. FDA/Brookings Meetings (expert workshops) of July 6th, 2014 and October 6th, 2014 at the Brookings Institution, Washington DC, USA.
  • Acquadro C. Genesis of the PRO Harmonization Group. In: Session 1: Advancing the Assessment of Outcomes Meaningful to Patients in Drug Development: A Brief History at the FDA and Beyond. Invited Presentation. Fifth Annual Patient-Reported Outcome (PRO) Consortium Workshop, April 29 - 30, 2014, Silver Spring, MD, USA.